Articles & Research
Awakened by cellular stress: isolation and characterization of a novel population of pluripotent stem cells derived from human adipose tissue. Heneidi S, Simerman AA, Keller E, Singh P, Li X, Dumesic DA, Chazenbalk G.PLoS One. 2013 Jun 5;8(6):e64752. doi: 10.1371/journal.pone.0064752. Print 2013.PMID: 23755141
Human adipose tissue possesses a unique population of pluripotent stem cells with nontumorigenic and low telomerase activities: potential implications in regenerative medicine. Ogura F, Wakao S, Kuroda Y, Tsuchiyama K, Bagheri M, Heneidi S, Chazenbalk G, Aiba S, Dezawa M.Stem Cells Dev. 2014 Apr 1;23(7):717-28. doi: 10.1089/scd.2013.0473. Epub 2014 Jan 17.PMID: 24256547
Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity. Chazenbalk G, Bertolotto C, Heneidi S, Jumabay M, Trivax B, Aronowitz J, Yoshimura K, Simmons CF, Dumesic DA, Azziz R.PLoS One. 2011 Mar 31;6(3):e17834. doi: 10.1371/journal.pone.0017834.PMID: 21483855
Amyotrophic Lateral Sclerosis patients treated with Pluripotent autologous adipose stem cells and case reports Cristina Bertolotto, CBVX-Stem Inc.Received 2022-09-07 | Accepted 2022-09-14 | Published: 2022-09-25. Journal of Stem Cell Biology and Transplantation.
Neural precursors express multiple chondroitin sulfate proteoglycans, including the lectican family. Kabos P, Matundan H, Zandian M, Bertolotto C, Robinson ML, Davy BE, Yu JS, Krueger RC Jr.Biochem Biophys Res Commun. 2004 Jun 11;318(4):955-63. doi: 10.1016/j.bbrc.2004.04.114.PMID: 15147965
Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis. Krakow D, Robertson SP, King LM, Morgan T, Sebald ET, Bertolotto C, Wachsmann-Hogiu S, Acuna D, Shapiro SS, Takafuta T, Aftimos S, Kim CA, Firth H, Steiner CE, Cormier-Daire V, Superti-Furga A, Bonafe L, Graham JM Jr, Grix A, Bacino CA, Allanson J, Bialer MG, Lachman RS, Rimoin DL, Cohn DH.Nat Genet. 2004 Apr;36(4):405-10. doi: 10.1038/ng1319. Epub 2004 Feb 29.PMID: 14991055
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, Perfetti R.Endocrinology. 2002 Nov;143(11):4397-408. doi: 10.1210/en.2002-220405.PMID: 12399437
Insulin and glucose regulate the expression of the DNA repair enzyme XPD. Merkel P, Khoury N, Bertolotto C, Perfetti R.Mol Cell Endocrinol. 2003 Mar 28;201(1-2):7585. doi: 10.1016/s0303-7207(02)00432-x. PMID: 12706296
Adipose-derived stem cells in patients with venous ulcers: Systematic review. Elsharkawi M, Ghoneim B, Westby D, Jones D, Tawfick W, Walsh SR.Vascular. 2023 Oct;31(5):989-993. doi: 10.1177/17085381221098279. Epub 2022 May 1.PMID: 35491989
The Efficacy of Stem Cells in Wound Healing: A Systematic Review. Farabi B, Roster K, Hirani R, Tepper K, Atak MF, Safai B.Int J Mol Sci. 2024 Mar 5;25(5):3006. doi: 10.3390/ijms25053006.PMID: 38474251
An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders. Rivera-Izquierdo M, Cabeza L, Láinez-Ramos-Bossini A, Quesada R, Perazzoli G, Alvarez P, Prados J, Melguizo C. Expert Opin Biol Ther. 2019 Mar;19(3):233-248. doi: 10.1080/14712598.2019.1563069. Epub 2019 Jan 25. PMID: 30653367 Review.
Stem Cells for Cartilage Regeneration: A Roadmap to the Clinic. Scotti C, Gobbi A, Nakamura N, Peretti GM. Stem Cells Int. 2018 Apr 11;2018:7348560. doi: 10.1155/2018/7348560. eCollection 2018.PMID: 29760735
Review of Caplan (1991) on cell-based therapeutic technology using Mesenchymal Stem Cells. Wakitani S, Mera H, Nakamura N, Gobbi A.J ISAKOS. 2024 Jun;9(3):426-430. doi: 10.1016/j.jisako.2023.08.010. Epub 2023 Sep 9. PMID: 37678637
Bone Marrow Aspirate Matrix: A Convenient Ally in Regenerative Medicine. Lana JF, da Fonseca LF, Azzini G, Santos G, Braga M, Cardoso Junior AM, Murrell WD, Gobbi A, Purita J, Percope de Andrade MA.Int J Mol Sci. 2021 Mar 9;22(5):2762. doi: 10.3390/ijms22052762.PMID: 33803231
Application of mesenchymal stem cell therapy for aging frailty: from mechanisms to therapeutics. Zhu Y, Ge J, Huang C, Liu H, Jiang H.Theranostics. 2021 Mar 31;11(12):5675-5685. doi: 10.7150/thno.46436. eCollection 2021.PMID: 33897874. Review.
Mesenchymal stem cells alleviate mouse liver fibrosis by inhibiting pathogenic function of intrahepatic B cells. Feng X, Feng B, Zhou J, Yang J, Pan Q, Yu J, Shang D, Li L, Cao H.Hepatology. 2025 Apr 1;81(4):1211-1227. doi: 10.1097/HEP.0000000000000831. Epub 2024 Mar 28.PMID: 38546278
Platelet-rich plasma injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios. Kon E, de Girolamo L, Laver L, Andriolo L, Andia I, Bastos R, Beaufils P, Biant L, Bøe B, Boffa A, Cugat R, Di Martino A, Erggelet C, Iosifidis M, Kocaoglu B, Magalon J, Marinescu R, Nehrer S, Niemeyer P, Ostojić M, Piontek T, Sánchez M, Sas K, Skarpas G, Tischer T, Vonk L, Filardo G.Knee Surg Sports Traumatol Arthrosc. 2024 Nov;32(11):2938-2949. doi: 10.1002/ksa.12320. Epub 2024 Jul 4.PMID: 38961773
Intravenously injected human multilineage-differentiating stress-enduring cells selectively engraft into mouse aortic aneurysms and attenuate dilatation by differentiating into multiple cell types. Hosoyama K, Wakao S, Kushida Y, Ogura F, Maeda K, Adachi O, Kawamoto S, Dezawa M, Saiki Y.J Thorac Cardiovasc Surg. 2018 Jun;155(6):2301-2313.e4. doi: 10.1016/j.jtcvs.2018.01.098. Epub 2018 Feb 21. PMID: 29559260
Outcomes at 2-Years Follow-Up After Hip Arthroscopy Combining Bone Marrow Concentrate. Rivera E, Seijas R, Rubio M, García-Balletbó M, Vilar JM, Boada PL, Cugat R.J Invest Surg. 2020 Aug;33(7):655-663. doi: 10.1080/08941939.2018.1535010. Epub 2019 Apr 7.PMID: 30957569
Advancing Parkinson's disease treatment: cell replacement therapy with neurons derived from pluripotent stem cells. Clark BJ, Lelos MJ, Loring JF. Stem Cells. 2024 Sep 10;42(9):781-790. doi: 10.1093/stmcls/sxae042. PMID: 38902932 Review.
Cell-Based Therapy for Stroke: Musing With Muse Cells. Park YJ, Niizuma K, Mokin M, Dezawa M, Borlongan CV.Stroke. 2020 Sep;51(9):2854-2862. doi: 10.1161/STROKEAHA.120.030618. Epub 2020 Aug 19. PMID: 32811374 Review.
Stem Cell Therapy for Erectile Dysfunction. Matz EL, Terlecki R, Zhang Y, Jackson J, Atala A.Sex Med Rev. 2019 Apr;7(2):321-328. doi: 10.1016/j.sxmr.2017.12.008. Epub 2018 Apr 7. PMID: 29631980 Review.
Platelet-Rich Plasma, Bone Marrow Aspirate Concentrate, and Hyaluronic Acid Injections Outperform Corticosteroids in Pain and Function Scores at a Minimum of 6 Months as Intra-Articular Injections for Knee Osteoarthritis: A Systematic Review and Network Metaanalysis. Jawanda H, Khan ZA, Warrier AA, Acuña AJ, Allahabadi S, Kaplan DJ, Ritz E, Jackson GR, Mameri ES, Batra A, Dornan G, Westrick J, Verma NN, Chahla J.Arthroscopy. 2024 May;40(5):1623-1636.e1. doi: 10.1016/j.arthro.2024.01.037. Epub 2024 Feb 7. PMID: 38331363
Orthobiologics for Meniscus Injuries. Villarreal-Espinosa JB, Gomez-Verdejo F, Bi AS, Fortier L, Chahla J.Clin Sports Med. 2025 Oct;44(4):775-788. doi: 10.1016/j.csm.2024.10.008. Epub 2025 Mar 11. PMID: 41101910 Review.
Ortho-Biologics for Ligament Repair and Reconstruction. Chahla J, Kennedy MI, Aman ZS, LaPrade RF.Clin Sports Med. 2019 Jan;38(1):97-107. doi: 10.1016/j.csm.2018.08.003.PMID: 30466725 Review.
Rogue stem cell clinics. Murray IR, Chahla J, Frank RM, Piuzzi NS, Mandelbaum BR, Dragoo JL; Members of the Biologics Association.Bone Joint J. 2020 Feb;102-B (2):148-154. doi: 10.1302/0301620X.102B2.BJJ-2019-1104.R1.PMID: 32009438
Current practice of biologic augmentation techniques to enhance the healing of meniscal repairs: A collaborative survey within the Meniscus International Network (MenIN) Study Group. Robinson J, Murray IR, Moatshe G, Chahla J, Tollefson LV, Parker DA, Familiari F, LaPrade RF, DePhillipo NN; Meniscus International Network (MenIN) Study Group.Knee Surg Sports Traumatol Arthrosc. 2026 Feb;34(2):436-444. doi: 10.1002/ksa.12685. Epub 2025 May 7. PMID: 40331602
Efficacy & safety of stem cell therapy for treatment of acute myocardial infarction: A systematic review & meta-analysis. Aggarwal P, Oza RR, Solanki H, Charan J, Kaur RJ, Deora S, Saini L, Kumar D, Choudhary R, Bhardwaj P, Kanchan T, Dutta S.Indian J Med Res. 2025 Jun;161(6):647-664. doi: 10.25259/IJMR_2185_2024.PMID: 40878346
Mesenchymal stem cell-derived exosomes in myocardial infarction: Therapeutic potential and application. Li J, Tang Y, Yin L, Lin X, Luo Z, Wang S, Yuan L, Liang P, Jiang B.J Gene Med. 2024 Jan;26(1): e3596. doi: 10.1002/jgm.3596. Epub 2023 Sep 19. PMID: 37726968 Review.
Single-cell dissection of cellular and molecular features underlying mesenchymal stem cell therapy in ischemic acute kidney injury. Wang W, Zhang M, Ren X, Song Y, Xu Y, Zhuang K, Xiao T, Guo X, Wang S, Hong Q, Feng Z, Chen X, Cai G.Mol Ther. 2023 Oct 4;31(10):3067-3083. doi: 10.1016/j.ymthe.2023.07.024. Epub 2023 Aug 2. PMID: 37533253
Stem Cell Therapy in the Treatment of Patients With Autism Spectrum Disorder: a Systematic Review and Meta-analysis. Villarreal-Martínez L, González-Martínez G, Sáenz-Flores M, Bautista-Gómez AJ, GonzálezMartínez A, Ortiz-Castillo M, Robles-Sáenz DA, Garza-López E.Stem Cell Rev Rep. 2022 Jan;18(1):155-164. doi: 10.1007/s12015-021-10257-0. Epub 2021 Sep 13. PMID: 34515938
Mesenchymal stromal cell therapy for chronic lung diseases: experimental and clinical evidence. Melo MM, Cruz FF, Rocco PRM.Expert Rev Respir Med. 2023 Mar;17(3):223-235. doi: 10.1080/17476348.2023.2196015. Epub 2023 Mar 28. PMID: 36964742 Review.
The aging lung: Physiology, disease, and immunity. Schneider JL, Rowe JH, Garcia-de-Alba C, Kim CF, Sharpe AH, Haigis MC.Cell. 2021 Apr 15;184(8):1990-2019. doi: 10.1016/j.cell.2021.03.005. Epub 2021 Apr 2. PMID: 33811810
Alzheimer's disease, dementia, and stem cell therapy. Duncan T, Valenzuela M.Stem Cell Res Ther. 2017 May 12;8(1):111. doi: 10.1186/s13287017-0567-5.PMID: 28494803
Stem Cells to the Rescue: Development and Application of CellBased Therapy for Microvascular Repair. Lerman LO, Lerman A.Cells. 2021 Aug 20;10(8):2144. doi: 10.3390/cells10082144.PMID: 34440914
Hematopoietic stem-cell gene therapy is associated with restored white matter microvascular function in cerebral adrenoleukodystrophy. Lauer A, Speroni SL, Choi M, Da X, Duncan C, McCarthy S, Krishnan V, Lusk CA, Rohde D, Hansen MB, Kalpathy-Cramer J, Loes DJ, Caruso PA, Williams DA, Mouridsen K, Emblem KE, Eichler FS, Musolino PL.Nat Commun. 2023 Apr 5;14(1):1900. doi: 10.1038/s41467023-37262-w.PMID: 37019892
Stem Cell Therapies for Treatment of Discogenic Low Back Pain: a Comprehensive Review. Urits I, Capuco A, Sharma M, Kaye AD, Viswanath O, Cornett EM, Orhurhu V.Curr Pain Headache Rep. 2019 Jul 29;23(9):65. doi: 10.1007/s11916-019-0804y.PMID: 31359164 Review.
Transplantation of three mesenchymal stem cells for knee osteoarthritis, which cell and type are more beneficial? a systematic review and network meta-analysis. Chen X, Zheng J, Yin L, Li Y, Liu H.J Orthop Surg Res. 2024 Jun 20;19(1):366. doi: 10.1186/s13018-024-04846-1.PMID: 38902778
Stem Cell-based Treatment Strategies for Degenerative Diseases of the Retina. Nair DSR, Thomas BB.Curr Stem Cell Res Ther. 2022;17(3):214-225. doi: 10.2174/1574888X16666210804112104.PMID: 34348629